Neural Regeneration Lab
RESEARCH
Production of specific neural and glial cells for regenerative therapy
<Experimental Tool>
Measurement of tissue and cellular stiffness during organogenesis (Iwashita et al, 2014Development)
In utero electroporation and tissue live imaging (Kosodo et al, 2011EMBO J)
High-efficient transplantation to the developing brain (Nagashima et al, 2014Stem Cells Dev)
<Research Topic>
Although mechanical properties have been shown to influence stem cell fate, little is known if mechanical properties of the stem cell niche change in vivo and whether and how this can influence behavior, growth and differentiation of stem cells.
We will seek mechanisms and logics how mechanical factors control differentiation towards specific neural and glial cells by systematic use of molecular biology, biochemistry, mouse genetics, material biology and advanced microscopy. Furthermore, we apply our knowledge to invent novel strategies for neural regeneration from human iPSCs against neurodegenerative diseases.
Measurement of tissue and cellular stiffness during organogenesis (Iwashita et al, 2014Development)
In utero electroporation and tissue live imaging (Kosodo et al, 2011EMBO J)
High-efficient transplantation to the developing brain (Nagashima et al, 2014Stem Cells Dev)
<Research Topic>
Although mechanical properties have been shown to influence stem cell fate, little is known if mechanical properties of the stem cell niche change in vivo and whether and how this can influence behavior, growth and differentiation of stem cells.
We will seek mechanisms and logics how mechanical factors control differentiation towards specific neural and glial cells by systematic use of molecular biology, biochemistry, mouse genetics, material biology and advanced microscopy. Furthermore, we apply our knowledge to invent novel strategies for neural regeneration from human iPSCs against neurodegenerative diseases.