We conduct multilevel research spanning molecules, cells, neural circuits, and behavior to investigate neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia, as well as neurodevelopmental disorders, rare diseases, and psychiatric disorders.

Our research explores protein and RNA homeostasis, mitochondrial and lysosomal functions, interactions among neurons, glial cells, and immune cells, the blood-brain barrier, and mechanisms of brain waste clearance. By integrating multi-omics, single-cell omics, and spatial omics analyses of patient-derived samples with artificial intelligence, we aim to identify biomarkers and therapeutic targets.

Based on mechanistic studies and efficacy validation using animal models and human-derived neurons, we investigate pharmaceuticals, nucleic acid therapeutics, neuromodulation, digital interventions, and brain tissue regeneration technologies to contribute to improving brain health and overcoming brain diseases.